With Cardinal Cushing's invitation to Maestra Paula to establish their Novitiate House in Boston, a new phase of development and growth was initiated in the American province. One after another, the Daughters of St Paul opened Book Centers and convents across the US. In fidelity to the Founder's inspiration and direction, the sisters sought to make their Book Centers “centers of light and warmth in Jesus Christ.”

Between 1957 and 1975, convents and book centers were established in Buffalo, Miami, Bridgeport, the Bronx, Oakland, Cleveland, New Orleans, Philadelphia, San Francisco, St Louis, Cincinnati, Honolulu, and Alaska.

From each of these locations, the sisters went door to door in homes and businesses, visiting people with the Word of God. It is from the Eucharist and their daily adoration before the Risen Christ that the sisters found the strength and the wisdom to be these “angels of the Lord” in the modern world. Alberione stated, "After receiving the Eucharist, we depart strengthened and spread the sweet odor of Christ.” These visits were often channels of grace in which people were brought back to the Church and the sacraments, marriages blessed, and new meaning found for life. Sr. Timothy Coniglio recalls from the years she was stationed in New Orleans this story: 

A couple of the Sisters were visiting a small town in Louisiana. We learned that a man in a small apartment was considering suicide. The sisters went there and knocked on his door but he wouldn't answer although he was home. Finally he came to the door but wasn't too polite. He refused any books and reluctantly accepted a leaflet, “Don't Quit.” Later, one of the sisters received a letter saying that he read the leaflet and it inspired him, and he put all thoughts of suicide out of his mind.

Meanwhile, in the Boston publishing house, there was a continuous effort to improve and multiply the books and periodicals being produced. By June of 1962, Publisher's Weekly reported that the sisters had published more than 300 titles and printed more than 3,000,000 copies. 

Mother Paula Cordero used to tell the sisters as they carried out their mission, “In giving us the apostolate of the media of social communication, our Founder has provided us with the means of reaching countless souls. And, as he pointed out, our apostolate will never grow old, for when new means of communications are invented, we will use them.”  

Beginning in the 1970s, the sisters expanded into the area of audiovisuals. They began producing slides, filmstrips, 16mm films, cassettes and records, although printing remained their most effective means of communication. They launched into English radio and the music apostolate, establishing the Daughters of St. Paul Choir. The James Alberione Sound and Video Studios were built in Boston in the 80s. Sister Maria Ruth Reyes, from Colombia, began the Spanish Radio apostolate which airs programs on hundreds of stations worldwide. Communities were founded in Chicago, Alexandria, Virginia, Seattle, Charleston, and in Los Angeles less than a mile from Lorimar, later Sony, Studios. 

In 1989 the house of Toronto, Ontario, merged with the U.S. province. The circumscription became known as the province of the United States and English Speaking Canada (US/ESC). In 1995 Rose Pacatte, FSP, founded the Pauline Center for Media Studies in Boston to develop “media mindfulness,” that is, media literacy, for parents and teachers within the context of culture, education, and faith formation. 

On February 13, 1991, Mother Paula died after almost 60 years of near continual presence in the United States. In every aspect of Pauline life, the province would feel her absence. 

In 1995 Rose Pacatte, FSP, founded the Pauline Center for Media Studies in Boston to develop “media mindfulness,” that is, media literacy, for parents and teachers within the context of culture, education, and faith formation. 

The Pauline apostolate is an ever widening horizon in which souls can be reached. The Christmas concert tour of the Daughters of St Paul choir, the websites, social media presence of so many of the sisters, Theology of the Body expertise and workshops, online groups and conferences for healing and hope, virtual vocation retreats, ebooks and audio books.... Like a mosaic the daughters of the great Apostle Paul follow him in their obedience to the Spirit who calls them into mission to announce Christ to the world. 

Blessed James Alberione often compared the mission of the Daughters of St. Paul to that of the priest, and he would add that while the priest gives Christ to those who come to church, the Daughters of Saint Paul reach even those who do not come. “Leave the sacrisities,” he would encourage us, “go in search of souls. Yours, too, is the mandate Jesus gave his apostles and priests: ‘Go and teach all nations.’”